5/5/2025
Last update
5/5/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 2 Enteric Coated Softgels
Amount Per Serving
%DV
Calories
25
Total Fat
2.5 g
4%†
Cholesterol
<5 mg
2%†
Pure+™ Wild Fish Oil ConcentrateYielding: EPA (eicosapentaenoic acid)DHA (docosahexaenoic acid)
2,000 mg700 mg500 mg
******
Polyphen-Oil™ Olive extract (fruit and leaf)[providing 19.5 mg polyphenols, 5.2 mg hydroxytyrosol/tyrosol, 4.4 mg verbascoside/oleuropein]
300 mg
**
Sesame seed lignan extract
10 mg
**
Top Medical Research Studies
8
We focused on how Resolvin D1 (RvD1), a pro-resolving lipid, impacts systemic lupus erythematosus (SLE). Our study measured RvD1 levels and T follicular helper (Tfh) cell counts in SLE patients versus healthy individuals.
We found that higher RvD1 levels correlated with lower disease activity and fewer Tfh cells. RvD1 was effective in reducing Tfh cell activity in a mouse model and inhibited Tfh differentiation in lab tests.
Overall, RvD1 appears to play a significant role in managing SLE by suppressing Tfh cells and influencing immune responses.
We found that higher RvD1 levels correlated with lower disease activity and fewer Tfh cells. RvD1 was effective in reducing Tfh cell activity in a mouse model and inhibited Tfh differentiation in lab tests.
Overall, RvD1 appears to play a significant role in managing SLE by suppressing Tfh cells and influencing immune responses.
7
We analyzed data from 18 randomized controlled trials involving 1018 rheumatoid arthritis (RA) patients to understand the effects of omega-3 supplementation. Our findings revealed that omega-3 significantly increased beneficial fatty acids, EPA, and DHA, while also decreasing harmful triglycerides and tender joint counts.
However, while some inflammation markers showed slight improvements, these changes were not statistically significant. Overall, omega-3 may help manage certain symptoms of RA, but the evidence remains mixed regarding its broader impact on inflammation.
However, while some inflammation markers showed slight improvements, these changes were not statistically significant. Overall, omega-3 may help manage certain symptoms of RA, but the evidence remains mixed regarding its broader impact on inflammation.
9
We explored the effects of a new, stable form of resolvin D1, called p-MPPF, on autoimmune encephalomyelitis, a condition affecting the nervous system. In our research, both p-MPPF and its unstable counterpart, RvD1, showed significant promise in reducing inflammation and improving symptoms.
This was evidenced by less severe disease progression, better spinal cord health, and changes in immune cell activity. Importantly, we discovered that both substances influenced immune cells in a way that avoids inflammation. Our findings suggest that these types of compounds could lead to improved treatments for autoimmune disorders.
This was evidenced by less severe disease progression, better spinal cord health, and changes in immune cell activity. Importantly, we discovered that both substances influenced immune cells in a way that avoids inflammation. Our findings suggest that these types of compounds could lead to improved treatments for autoimmune disorders.
Most Useful Reviews
9
Eczema relief
1 people found this helpful
My experience with this product has been great. The capsules are smaller at 500mg, making them easy to swallow compared to the standard size. When bitten, they taste of olive oil with rosemary and lack the fishy smell. I take a prophylactic dose of two capsules daily. My skin is now more hydrated and elastic, with dryness disappearing. My palms, prone to eczema, remain smooth, and if I do develop it, it heals quickly. Omega-3 from Life Extension is high quality and effective.
7.5
Skin improvement
7 people found this helpful
This is not the first time I have ordered this Omega 3. Excellent quality and good dosage. I purchased the first jar upon a beautician's recommendation due to dryness on my feet. After a week of taking it, I noticed significant improvement. The capsules are large, matte, and opaque, but not difficult to swallow. Each capsule contains oily liquid, not jelly as mentioned in some reviews. I take one capsule twice a day along with vitamin C.
9
Nail strength
6 people found this helpful
My nails were strengthened and my skin tone evened out. This Omega is exceptional! My nails, which were previously peeling, became much tougher after a month of taking these capsules. Moreover, the tone of my face has smoothed out, with fewer rashes. I highly recommend this product and I am ordering my second jar. Taking more capsules at once is more economical.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
- All Researches
9
We explored the effects of a new, stable form of resolvin D1, called p-MPPF, on autoimmune encephalomyelitis, a condition affecting the nervous system. In our research, both p-MPPF and its unstable counterpart, RvD1, showed significant promise in reducing inflammation and improving symptoms.
This was evidenced by less severe disease progression, better spinal cord health, and changes in immune cell activity. Importantly, we discovered that both substances influenced immune cells in a way that avoids inflammation. Our findings suggest that these types of compounds could lead to improved treatments for autoimmune disorders.
This was evidenced by less severe disease progression, better spinal cord health, and changes in immune cell activity. Importantly, we discovered that both substances influenced immune cells in a way that avoids inflammation. Our findings suggest that these types of compounds could lead to improved treatments for autoimmune disorders.
8
Omega-3s may improve SLE outcomes
We explored the effects of omega-3 fatty acids on systemic lupus erythematosus (SLE) using data from 418 participants. Our analysis focused on how different fatty acids relate to disease activity, pain, and sleep quality.
The results highlight that higher levels of long-chain omega-3 fatty acids, particularly DHA, are linked to better outcomes in SLE patients. Although our findings support the idea that omega-3s can be beneficial, more research is needed to confirm these benefits and their long-term effects.
This suggests that improving omega-3 intake through diet could be an effective strategy for managing SLE.
The results highlight that higher levels of long-chain omega-3 fatty acids, particularly DHA, are linked to better outcomes in SLE patients. Although our findings support the idea that omega-3s can be beneficial, more research is needed to confirm these benefits and their long-term effects.
This suggests that improving omega-3 intake through diet could be an effective strategy for managing SLE.
8
We explored the protective effects of omega-3 fatty acids on insulin-producing cells, particularly focusing on their role in reducing inflammation related to type 1 diabetes. Our findings suggest that omega-3s boost a protein called ARH3, which helps lower the expression of a harmful chemokine, CXCL9.
This mechanism seems to shield β cells from autoimmune attacks, potentially decreasing the risk of developing type 1 diabetes. Overall, while omega-3s show promise as an anti-inflammatory agent, the full impact on autoimmune disorders necessitates further investigation.
This mechanism seems to shield β cells from autoimmune attacks, potentially decreasing the risk of developing type 1 diabetes. Overall, while omega-3s show promise as an anti-inflammatory agent, the full impact on autoimmune disorders necessitates further investigation.
8
We explored the relationship between omega-3 fatty acids and autoimmune disorders, conducting a comprehensive review and Mendelian randomization analysis.
Our findings indicate that omega-3s provide benefits primarily for rheumatoid arthritis and systemic lupus erythematosus, improving disease activity and reducing inflammation.
However, there was no strong evidence supporting their effectiveness against other autoimmune conditions like psoriasis and multiple sclerosis. This suggests that while omega-3s may benefit certain illnesses, more research is needed for others.
Our findings indicate that omega-3s provide benefits primarily for rheumatoid arthritis and systemic lupus erythematosus, improving disease activity and reducing inflammation.
However, there was no strong evidence supporting their effectiveness against other autoimmune conditions like psoriasis and multiple sclerosis. This suggests that while omega-3s may benefit certain illnesses, more research is needed for others.
8
We conducted a multicentre, randomised, double-blind, placebo-controlled trial to examine how omega-3 fish oil, specifically from krill oil concentrate (KOC), affects patients with systemic lupus erythematosus (SLE).
Our research showed that KOC effectively corrected omega-3 deficiency and led to a decrease in disease activity for patients with more severe symptoms.
While outcomes were promising, we believe that further studies are necessary to confirm the long-term benefits of omega-3 supplementation for managing lupus.
Our research showed that KOC effectively corrected omega-3 deficiency and led to a decrease in disease activity for patients with more severe symptoms.
While outcomes were promising, we believe that further studies are necessary to confirm the long-term benefits of omega-3 supplementation for managing lupus.
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eczema relief
1 people found this helpful
My experience with this product has been great. The capsules are smaller at 500mg, making them easy to swallow compared to the standard size. When bitten, they taste of olive oil with rosemary and lack the fishy smell. I take a prophylactic dose of two capsules daily. My skin is now more hydrated and elastic, with dryness disappearing. My palms, prone to eczema, remain smooth, and if I do develop it, it heals quickly. Omega-3 from Life Extension is high quality and effective.
7.5
Skin improvement
7 people found this helpful
This is not the first time I have ordered this Omega 3. Excellent quality and good dosage. I purchased the first jar upon a beautician's recommendation due to dryness on my feet. After a week of taking it, I noticed significant improvement. The capsules are large, matte, and opaque, but not difficult to swallow. Each capsule contains oily liquid, not jelly as mentioned in some reviews. I take one capsule twice a day along with vitamin C.
9
Nail strength
6 people found this helpful
My nails were strengthened and my skin tone evened out. This Omega is exceptional! My nails, which were previously peeling, became much tougher after a month of taking these capsules. Moreover, the tone of my face has smoothed out, with fewer rashes. I highly recommend this product and I am ordering my second jar. Taking more capsules at once is more economical.
6
Inflammation reduction
1 people found this helpful
This product has no fishy aftertaste and is of great quality from a good source, offering excellent value for money. I am hopeful that with this order, I can reduce inflammation in my body and enhance my cognitive function.
Frequently Asked Questions
7.5
Skin improvement
7 people found this helpful
This is not the first time I have ordered this Omega 3. Excellent quality and good dosage. I purchased the first jar upon a beautician's recommendation due to dryness on my feet. After a week of taking it, I noticed significant improvement. The capsules are large, matte, and opaque, but not difficult to swallow. Each capsule contains oily liquid, not jelly as mentioned in some reviews. I take one capsule twice a day along with vitamin C.
9
Nail strength
6 people found this helpful
My nails were strengthened and my skin tone evened out. This Omega is exceptional! My nails, which were previously peeling, became much tougher after a month of taking these capsules. Moreover, the tone of my face has smoothed out, with fewer rashes. I highly recommend this product and I am ordering my second jar. Taking more capsules at once is more economical.
9
Eczema relief
1 people found this helpful
My experience with this product has been great. The capsules are smaller at 500mg, making them easy to swallow compared to the standard size. When bitten, they taste of olive oil with rosemary and lack the fishy smell. I take a prophylactic dose of two capsules daily. My skin is now more hydrated and elastic, with dryness disappearing. My palms, prone to eczema, remain smooth, and if I do develop it, it heals quickly. Omega-3 from Life Extension is high quality and effective.
6
Inflammation reduction
1 people found this helpful
This product has no fishy aftertaste and is of great quality from a good source, offering excellent value for money. I am hopeful that with this order, I can reduce inflammation in my body and enhance my cognitive function.
8
Omega-3s may improve SLE outcomes
We explored the effects of omega-3 fatty acids on systemic lupus erythematosus (SLE) using data from 418 participants. Our analysis focused on how different fatty acids relate to disease activity, pain, and sleep quality.
The results highlight that higher levels of long-chain omega-3 fatty acids, particularly DHA, are linked to better outcomes in SLE patients. Although our findings support the idea that omega-3s can be beneficial, more research is needed to confirm these benefits and their long-term effects.
This suggests that improving omega-3 intake through diet could be an effective strategy for managing SLE.
The results highlight that higher levels of long-chain omega-3 fatty acids, particularly DHA, are linked to better outcomes in SLE patients. Although our findings support the idea that omega-3s can be beneficial, more research is needed to confirm these benefits and their long-term effects.
This suggests that improving omega-3 intake through diet could be an effective strategy for managing SLE.
8
We conducted a multicentre, randomised, double-blind, placebo-controlled trial to examine how omega-3 fish oil, specifically from krill oil concentrate (KOC), affects patients with systemic lupus erythematosus (SLE).
Our research showed that KOC effectively corrected omega-3 deficiency and led to a decrease in disease activity for patients with more severe symptoms.
While outcomes were promising, we believe that further studies are necessary to confirm the long-term benefits of omega-3 supplementation for managing lupus.
Our research showed that KOC effectively corrected omega-3 deficiency and led to a decrease in disease activity for patients with more severe symptoms.
While outcomes were promising, we believe that further studies are necessary to confirm the long-term benefits of omega-3 supplementation for managing lupus.
7
We explored how diet might influence the risk of developing rheumatoid arthritis (RA) using a detailed Mendelian randomisation analysis. By examining data from extensive genome-wide association studies, we focused on twenty-two dietary factors. Our findings highlighted a notable genetic connection: higher intake of oily fish was linked to a lower risk of RA. Specifically, those who consumed oily fish showed a protective effect. Other dietary factors didn’t show significant relationships. This study emphasizes the potential benefits of adjusting one’s diet, particularly incorporating more oily fish for those at risk of RA.
7
We explored the relationship between omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk using data from the National Health and Nutrition Examination Survey between 1999 and 2020.
After analyzing dietary information from over 50,000 participants, we found a negative correlation indicating that higher consumption of these fatty acids may reduce the risk of developing rheumatoid arthritis.
This suggests that incorporating omega-3 and omega-6 fats into our diet could be beneficial for reducing arthritis risk in adults.
After analyzing dietary information from over 50,000 participants, we found a negative correlation indicating that higher consumption of these fatty acids may reduce the risk of developing rheumatoid arthritis.
This suggests that incorporating omega-3 and omega-6 fats into our diet could be beneficial for reducing arthritis risk in adults.
8
We explored the relationship between omega-3 fatty acids and autoimmune disorders, conducting a comprehensive review and Mendelian randomization analysis.
Our findings indicate that omega-3s provide benefits primarily for rheumatoid arthritis and systemic lupus erythematosus, improving disease activity and reducing inflammation.
However, there was no strong evidence supporting their effectiveness against other autoimmune conditions like psoriasis and multiple sclerosis. This suggests that while omega-3s may benefit certain illnesses, more research is needed for others.
Our findings indicate that omega-3s provide benefits primarily for rheumatoid arthritis and systemic lupus erythematosus, improving disease activity and reducing inflammation.
However, there was no strong evidence supporting their effectiveness against other autoimmune conditions like psoriasis and multiple sclerosis. This suggests that while omega-3s may benefit certain illnesses, more research is needed for others.
8
We explored the protective effects of omega-3 fatty acids on insulin-producing cells, particularly focusing on their role in reducing inflammation related to type 1 diabetes. Our findings suggest that omega-3s boost a protein called ARH3, which helps lower the expression of a harmful chemokine, CXCL9.
This mechanism seems to shield β cells from autoimmune attacks, potentially decreasing the risk of developing type 1 diabetes. Overall, while omega-3s show promise as an anti-inflammatory agent, the full impact on autoimmune disorders necessitates further investigation.
This mechanism seems to shield β cells from autoimmune attacks, potentially decreasing the risk of developing type 1 diabetes. Overall, while omega-3s show promise as an anti-inflammatory agent, the full impact on autoimmune disorders necessitates further investigation.
References
- Gilley KN, Fenton JI, Zick SM, Li K, Wang L, et al. Serum fatty acid profiles in systemic lupus erythematosus and patient reported outcomes: The Michigan Lupus Epidemiology & Surveillance (MILES) Program. Front Immunol. 2024;15:1459297. 10.3389/fimmu.2024.1459297
- You Y, Sarkar S, Deiter C, Elliott EC, Nicora CD, et al. Reduction of Chemokine CXCL9 Expression by Omega-3 Fatty Acids via ADP-Ribosylhydrolase ARH3 in MIN6 Insulin-Producing Cells. Proteomics. 2025;25:e202400053. 10.1002/pmic.202400053
- Wang Y, Hu S, Zhang W, Zhang B, Yang Z. Dietary factors and rheumatoid arthritis: new perspectives from a Mendelian randomisation analysis. Br J Nutr. 2025;133:107. 10.1017/S0007114524002721
- Nave CBD, Pereira P, Silva ML. The Effect of Polyunsaturated Fatty Acid (PUFA) Supplementation on Clinical Manifestations and Inflammatory Parameters in Individuals with Sjögren's Syndrome: A Literature Review of Randomized Controlled Clinical Trials. Nutrients. 2024;16. 10.3390/nu16213786
- Szczuko M, Kacprzak J, Przybylska A, Szczuko U, Pobłocki J, et al. The Influence of an Anti-Inflammatory Gluten-Free Diet with EPA and DHA on the Involvement of Maresin and Resolvins in Hashimoto's Disease. Int J Mol Sci. 2024;25. 10.3390/ijms252111692
- Hong K, Hun M, Wu F, Mao J, Wang Y, et al. Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian randomization analysis. Autoimmun Rev. 2024;23:103651. 10.1016/j.autrev.2024.103651
- Zhang Q, Zhang Y, Zou M, Wu H, Liu C, et al. The chemically stable analogue of resolvin D1 ameliorates experimental autoimmune encephalomyelitis by mediating the resolution of inflammation. Int Immunopharmacol. 2024;140:112740. 10.1016/j.intimp.2024.112740
- Salmon J, Wallace DJ, Rus V, Cox A, Dykas C, et al. Correction of omega-3 fatty acid deficiency and improvement in disease activity in patients with systemic lupus erythematosus treated with krill oil concentrate: a multicentre, randomised, double-blind, placebo-controlled trial. Lupus Sci Med. 2024;11. 10.1136/lupus-2024-001201
- Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. 10.1007/s10067-024-07040-0
- Cervantes A, Hughes FM, Jin H, Purves JT. Specialized pro-resolution mediators in the bladder: effects of resolvin E1 on diabetic bladder dysfunction in the type 1 diabetic male Akita mouse model. BMC Urol. 2024;24:130. 10.1186/s12894-024-01519-3
- Chen Y, Li Z, Gao Y, Xu B, Zhang W, et al. Fish oil supplementation and risk of incident systemic lupus erythematosus: a large population-based prospective study. Nutr J. 2024;23:63. 10.1186/s12937-024-00965-x
- Kang T, Xi Y, Qian T, Lu S, Du M, et al. Exploring the link between dietary omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk: NHANES 1999-2020 study. Clin Exp Rheumatol. 2024;42:1720. 10.55563/clinexprheumatol/91tmfb
- Laevski AM, Doucet MR, Doucet MS, LeBlanc AA, Pineau PE, et al. Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model. Eur J Nutr. 2024;63:2221. 10.1007/s00394-024-03397-9
- Huang L, Wu J, Cao J, Sheng X, Wang M, et al. Resolvin D1 inhibits T follicular helper cell expansion in systemic lupus erythematosus. Scand J Rheumatol. 2024;53:276. 10.1080/03009742.2024.2344906
- Lin X, Zarghami A, Jelinek GA, Simpson-Yap S, Neate S, et al. Diet and omega-3 and vitamin D supplement use predict five-year fatigue and disability trajectories in people with multiple sclerosis. Mult Scler Relat Disord. 2024;86:105615. 10.1016/j.msard.2024.105615
- Costenbader KH, Cook NR, Lee IM, Hahn J, Walter J, et al. Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial. Arthritis Rheumatol. 2024;76:973. 10.1002/art.42811
